工艺与制造英文2020被引 20
通过Annexin A1结合肽突破血脑屏障靶向脑肿瘤
Overcoming the blood–brain barrier by Annexin A1-binding peptide to target brain tumours
Motohiro Nonaka, Misa Suzuki‐Anekoji, Jun Nakayama, Hideaki Mabashi‐Asazuma, Donald L. Jarvis, Jiunn-Chern Yeh, Kazuhiko Yamasaki, Tomoya O. Akama, Chun‐Teng Huang, Alexandre Rosa Campos, Masato Nagaoka, T. Sasai, Itsuko Kimura‐Takagi, Yoichi Suwa, Takashi Yaegashi, Toshiaki Shibata, Kazuhiro Sugihara, Chizuko Nishizawa-Harada, Minoru Fukuda, Michiko N. Fukuda · Kyoto University
摘要整理
血脑屏障（BBB）的存在严重限制了脑肿瘤治疗药物的脑部递送效率。本研究开发了IF7C(RR)-SN38偶联物，该化合物通过Annexin A1介导的机制有效穿透血脑屏障，在小鼠脑肿瘤模型中显著抑制肿瘤生长。采用Solutol HS15作为药物递送载体进行制剂化处理后，IF7C(RR)-SN38不仅能够有效跨越血脑屏障到达脑肿瘤部位，而且可能通过激发机体抗肿瘤免疫应答而增强治疗效果。该研究为开发新型脑肿瘤靶向治疗药物提供了重要的技术路线，具有重要的临床转化潜力。
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