工艺与制造英文2021被引 36
同步辐射显微CT多尺度表征组织结构的方法——以人胎盘为例
A massively multi-scale approach to characterizing tissue architecture by synchrotron micro-CT applied to the human placenta
Win Tun, Gowsihan Poologasundarampillai, Helen Bischof, Gareth Nye, Oliver N. F. King, Mark Basham, Yasuaki Tokudome, Rohan M. Lewis, Edward Johnstone, Paul Brownbill, Michele C. Darrow, Igor L. Chernyavsky · Diamond Light Source
摘要整理
生物软组织的多尺度结构评估具有挑战性但对揭示组织/器官的结构-功能关系至关重要。本研究以人胎盘为研究对象，整合了先进的样品制备方案、高端成像技术和经过验证的机器学习分割算法，首次获得了大规模多尺度、多域信息，能够对胎盘的母体域和胎儿域进行详细的形态学和功能分析。研究量化了异质性胎盘组织形态学指标中的尺度依赖误差，估算了提取有意义生物学数据所需的最小组织尺度。所建立的方案有利于高通量研究正常和病理胎盘的结构-功能关系，为病理妊娠的治疗方案优化提供支持。此外，该方法学对于具有类似胎盘特征的其他复杂器官（具有循环血管和非血管流体间隙的交换屏障）的组织结构和生理行为表征同样适用。
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