工艺与制造英文2024被引 4
肝动脉化疗栓塞超越肝细胞癌：我们能治疗哪些肿瘤及何时治疗？
Chemoembolization Beyond Hepatocellular Carcinoma: What Tumors Can We Treat and When?
Daniel M. DePietro, Xin Li, Susan Shamimi‐Noori · University of Pennsylvania
摘要整理
肝转移瘤是肝脏中最常见的恶性肿瘤，其发生率比原发性肝肿瘤（包括肝细胞癌）高20~40倍。肝转移瘤患者多表现为晚期病变，不适合根治性手术或消融治疗。肝转移瘤独特的肝动脉血供特点使介入放射学医生能够利用经动脉治疗靶向治疗这些肿瘤。经动脉化疗栓塞（TACE）已被用于治疗来自多种原发肿瘤的肝转移瘤，在肝脏无进展生存期、总生存期和症状缓解等方面均显示出临床获益。根据原发肿瘤的不同来源，肝转移瘤的TACE治疗指征、栓塞方案和技术选择各不相同，术后效果也存在差异。本综述阐述了TACE技术及肝转移瘤治疗的具体考虑因素，深入分析了TACE在结直肠癌、神经内分泌肿瘤和葡萄膜黑色素瘤肝转移瘤治疗中的应用，这些肿瘤代表了肝细胞癌之外众多可通过TACE治疗的肿瘤类型，并总结了在治疗算法中何时应考虑采用TACE的相关证据。
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