工艺与制造英文2022被引 27
放射性栓塞治疗神经内分泌肿瘤肝转移的临床应用进展
The Evolving Role of Radioembolization in the Treatment of Neuroendocrine Liver Metastases
Khalil Ramdhani, Arthur J. A. T. Braat · University Medical Center Utrecht
摘要整理
神经内分泌肿瘤（NET）确诊时21-50%患者已存在远处转移，其中肝脏是最常见的转移部位。神经内分泌肿瘤肝转移（NELM）的存在是影响患者生存预后的最重要因素。NELM确诊时，60-70%患者呈现双叶多灶性病变，不适合手术切除。由于全身治疗手段有限，肝脏靶向治疗存在临床需求。经动脉栓塞、化学栓塞和放射性栓塞等血管介入治疗在NELM治疗中应用日益增多。近年来，放射性栓塞（也称选择性内放射治疗，SIRT）因其具有良好的肿瘤缩小效果、毒性反应有限和科学证据不断增加而受到广泛关注。本综述阐述了放射性栓塞的基本技术原理，总结了NELM放射性栓塞治疗的现有文献证据，并讨论了在NELM治疗中应用放射性栓塞的注意事项、挑战和新进展。
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